Top 3 Core Administrative Processing Systems Software Companies $100M+ Revenue (September 2026)

Boston, Massachusetts, United States

Zelis is modernizing the healthcare financial experience by providing a connected platform that bridges the gaps and aligns interests across payers, providers, and healthcare consumers. This platform serves more than 750 payers, including the top 5 national health plans, regional health plans, TPAs and self-insured employers, and millions of healthcare providers and consumers. Zelis sees across the system to identify, optimize, and solve problems holistically with technology built by healthcare experts – driving real, measurable results for clients. Zelis maintains a transparent, fee-free recruitment process. All genuine offers originate from our Talent Acquisition team using the “@ zelis.com” domain. We do not use WhatsApp or personal emails for recruitment. Forward any suspected fraud to verify-offers[@]zelis.com for prompt investigation. Thank you for staying vigilant.

Boston, Massachusetts, United States

HealthEdge is on a mission to drive a digital transformation in healthcare. We’re connecting health plans, providers, and patients with end-to-end digital technology solutions to support new business models, reduce administrative costs and improve health outcomes. Our growing portfolio of products (HealthRules® Payer, HealthEdge Source™, HealthEdge® Provider Data Management, GuidingCare®, and Wellframe™) provides talented and passionate professionals with opportunities to lead change and make a lasting, global impact in healthcare. Driving our mission are 2,000+ professionals worldwide. Together, we are committed to innovating a world where healthcare can focus on people.

Chicago, Illinois, United States

Veradigm is an integrated data systems and services company that combines data-driven clinical insights with actionable tools to help healthcare stakeholders improve the quality, efficiency, and value of healthcare delivery—these stakeholders include biopharma, health plans, healthcare providers, network partners, and most importantly, the patients they serve. We build solutions that are designed to help healthcare stakeholders to improve patient lives through data driven insights. We are dedicated to simplifying the complicated healthcare system with next-generation technology and solutions, transforming healthcare from the point-of-patient care to everyday life. As a result, Veradigm attracts leaders in healthcare, technology, and innovation, seeking to work with us to deliver insights and solutions to the benefit the healthcare ecosystem with the objective being to improve healthcare quality while lowering the cost of healthcare. Veradigm is an organization comprised of passionate and energetic people whose everyday focus is on helping all healthcare stakeholders drive the best care possible for healthier communities. We believe diversity is the foundation of innovation, and we are dedicated to fostering an inclusive environment that supports the talents of all people.