Top 42 SaaS Companies in Cape Town, South Africa, May 2026

Cape Town, Western Cape, South Africa

Jembi Health Systems NPC, is a nonprofit organisation that works in developing countries in Africa and focuses on the development of eHealth and health information systems (HIS). Jembi leads the way on building local capacity within Africa through innovation and commitment towards strengthening of eHealth. Its head office is in Cape Town, South Africa. The NGO was started by Dr Chris Seebregts in 2009 and has since grown rapidly to provide infrastructural support for projects and offices in several African countries, including South Africa, Mozambique, Rwanda, Zambia and, increasingly, other African countries. Jembi’s Head Office is based in Tokai, Cape Town, South Africa. Project/satellite offices are based in Maputo, Kigali and Lusaka.

Cape Town, Western Cape, South Africa

In the business of creating technology solutions that service the global tourism industry, Wetu offers a product to both the operator and supplier markets. For operators (DMC’s, DMO’s, Travel Agents and Tour Operators), Wetu’s Itinerary Builder allows beautifully curated, visual itineraries to be created using up-to-date content at any time of the day. For Suppliers (Accommodations, Activities, Restaurants and Day- Tour providers), Wetu not only offers a centralised content management system but also provides exposure to a global trade network. Wetu strongly believes that for businesses to thrive, connection and collaboration needs to lie at its core.

Cape Town, Western Cape, South Africa

At GlueData, we are exclusively SAP data experts. Our focus may be niche, but our passion and expertise are immense. We’ve been steadfast in our goal to help our clients manage, migrate and optimise their data since inception, giving us unparalleled depth of knowledge and experience in our specialist field. Quite simply, we enable our clients to attain and sustain quality data, maximising the value from their SAP investment.

Cape Town, South Africa

DataProphet is a global leader in Artificial Intelligence (AI) for manufacturing

Cape Town, Western Cape, South Africa

IronTree is an award-winning data backup, cybersecurity and disaster recovery managed service provider (MSP). Our SecureIT Suite of products includes StoreIT, ProtectIT, HostIT, RecoverIT and ComplyIT. Most importantly, our service team is world-class - a reason for winning 'Best Service Provider' in the MEA Region in 2021. Cloud/Online/Offsite Data Backup Fully managed Disaster Recovery as a Service (DRaaS(FM)) Cloud-hosted Ransomware Protection Hosted Exchange Email Business Continuity Planning - A complete compliance management solution for POPIA (The Protection of Personal Information Act) IronTree was established in 2007 and is one of the largest providers of hosted continuity solutions to South African businesses, with more than 16,000 companies utilising its services daily.