As of November 2026, Latka tracks 19 clinical decision support SaaS companies with $10M–$100M in annual revenue. They have combined revenues of $434.7M and employ 2.1K people. They have raised $685.8M and serve 800 customers combined.
Every company below sells clinical decision support software to other businesses and is ranked by its most recent annual revenue. Revenue, funding, headcount and customer figures come from CEO interviews on the Latka podcast, public company filings, and Latka estimates where a company has not disclosed a number.
Clinical Decision Support (CDS) systems are advanced software applications designed to assist healthcare professionals in making informed clinical decisions. By integrating patient data with clinical knowledge and guidelines, these systems provide tailored recommendations for diagnosing, treating, and managing patient care. Typical features include alert systems for drug interactions, clinical reminders, diagnostic support tools, and analytics that leverage large datasets to improve healthcare outcomes. The primary users of clinical decision support systems include physicians, nurses, and other healthcare professionals involved in patient care. By utilizing these systems, medical practitioners can enhance the quality of care they provide, reduce errors, and streamline workflows. Common workflows may include patient assessment, decision-making based on evidence-based guidelines, and ongoing patient monitoring, all aimed at ensuring optimal patient outcomes.
Sorting: Highest -> Lowest
Showing 10 of 19 companies ranked by annual revenue.
New York, New York, United States
SmarterDx builds clinical AI that empowers hospitals to review 100% of patient charts, appeal every denial, and achieve their full revenue integrity potential.
Cambridge, Massachusetts, United States
OpenEvidence is the leading medical information platform that offers an AI-powered platform organizing and expanding medical knowledge for clinicians, providing real-time, evidence-based answers.
Cambridge, Massachusetts, United States
Developer of an artificial intelligence powered life sciences software platform designed to synthesize the exponentially growing biomedical knowledge. The company's platform uses neural networks (shallow and deep learning models) for real-time, automated extraction of knowledge from the scientific, regulatory and commercial body of literature, enabling healthcare enterprises to make biomedical knowledge computable.
Los Altos, California, United States
A leading precision medicine company developing AI tests to personalize cancer therapy.
Larkspur, California, United States
Caresyntax is a digital surgery platform that enables OR teams to predict and improve surgical performance. It is focused on making surgery safer and smarter by converging AI-powered software, devices, and clinical services.
Tel Aviv, Israel
Scopio Labs is transforming cell morphology analysis, offering fully digital applications, platforms, and diagnostic support that enhance clinical workflows. By assisting lab experts with fast, early, and accurate detection and diagnosis of disease, Scopio expedites patients' access to life-saving treatments. .
San Diego, California, United States
We are advancing care for arrhythmia patients by unlocking insights contained in a standard ECG. vMap is an arrhythmia analysis tool developed with AI.
Modi'in, HaMerkaz, Israel
FIZE Medical is focused on bringing the future of AI-powered fluid management to ICU today. Our technology takes the guesswork away from the kidney functioning status enabling early detection of deterioration and adjustment of therapy for improved patient outcomes.
New York, New York, United States
Leading AI-enabled diagnostic technology company focused on radiology performance measurement and impact and driving quality performance
Latka tracks 19 clinical decision support SaaS companies with $10M–$100M in annual revenue. Together they generate $434.7M in annual revenue and employ 2.1K people.
SmarterDx is the largest, with $71M in annual revenue, founded in 2020.
The average clinical decision support SaaS company in this list makes $22.9M a year, across 19 companies with reported revenue. They serve 800 customers combined.
Ranked by annual revenue, the leaders are SmarterDx, OpenEvidence, nference, Prognos Health and ArteraAI.
The 19 clinical decision support SaaS companies with $10M–$100M in annual revenue tracked here have raised $685.8M in disclosed funding between them.
- The product must provide actionable insights and recommendations based on clinical data. - It should integrate with electronic health records (EHR) and other clinical systems. - The solution must support evidence-based guidelines and alerts for healthcare providers. - It should enhance clinical workflows, aiding in both diagnosis and treatment plans. - The product is not just an EHR system; it must specifically provide clinical decision support functionalities.
