Top 11 Population Health Management Software Companies With $1M–$5M Revenue (September 2026)

Pittsburgh, Pennsylvania, United States

Developer of a health data management and analytics platform designed to uncover insights from disparate silos of benefit and risk data. The company's platform integrates and validates all data sources into a single secure cloud space to help users gain control of their data and generate a 360-degree view of their population, enabling clients to use the total rewards and risk data differently to manage and mitigate business and population risk easily.

Tampa, Florida, United States

Developer of a cloud-based population health and care management platform designed to provide integrated value-based care. The company's SaaS platform service features customizable tools to the payer and provider markets, including person-centered care/case management, disease management, utilization management, interdisciplinary collaborative workflows, broad-spectrum interoperability, patient engagement and configurable analytics and reporting, enabling healthcare organizations to achieve enhanced outcomes while maximizing efficiency, improving transparency and lowering costs.

Bala Cynwyd, Pennsylvania, United States

100Plus, a Connect America Company, empowers physicians and healthcare organizations in managing their patients with chronic conditions remotely, proactively engaging them to avoid episodic care, and driving a higher quality of life. In addition, 100Plus offers an end-to-end solution, including patient outreach, device setup, patient engagement, and automatic bill generation. Our solution includes Esper, a powerful AI-assisted technology that acts as a virtual physician assistant to enable better care coordination and patient engagement and reduces the burden on physician staff for non-reimbursable administrative work.

Cambridge, Cambridge, United Kingdom

TidalSense is a respiratory technology company building AI-driven diagnostic and monitoring technologies for COPD and asthma, aimed at revolutionizing population-level outcomes for respiratory patients.

Atlanta, Georgia, United States

ChronicCareIQ was found by Matt Ethington in 2015. The founder was diagnosed with Type 1 Diabetes at the age of 30, a highly unusual and late diagnosis for a type 1 diabetic. Matt quickly discovered and learned about the patient experience in a chronic care management process and the disconnect between patients and physicians. ChronicCareIQ's enables physicians and hospitals to stay better connected to their patients. CCIQ's connected care platform is an all in one tool-kit for physicians to provide chronic care management, remote patient monitoring, and transitional care management for their patient population. CCIQ is an early warning system to know when fragile and chronic patients require your attention. Patients respond to automated, algorithm driven electronic queries via smart phone app, text, email, desktop or tablet. Queries match patient health profiles and are dynamic to detect disease progression, decompensation, change in symptoms and patient status. Those, whose resp

Vancouver, BC, Canada

Equicare Health is the industry’s leading provider of comprehensive care coordination software that improves clinical outcomes for patients, optimizes revenue generation, and enables care providers to operate more effectively. Equicare’s web-based solution, EQUICARE CS™, includes functionality for patient navigation, long-term follow-up, and patient engagement. Equicare delivers services through interfaces with a variety of Hospital Information Systems to assist centers in managing large patient populations with minimal administrative overhead. EQUICARE CS™ is a self-funding, CoC-compliant patient engagement solution that supports patients throughout the care continuum, and is used in hospitals and care centers around the world. There are currently over 10 million cancer survivors living in the United States, plus an estimated 1.4 million new cases are diagnosed every year, (figures from the National Cancer Institute). The Institute of Medicine, which published a landmark study "From Cancer Patient to Cancer Survivor: Lost in Transition,"​ has shown that cancer is no longer a disease that is resolved through acute treatment alone; rather, it is a chronic disease that requires lifelong care. Cancer centers specialize in the acute treatment phase and are best equipped to manage the chronic treatment, or survivorship, phase as well, due to their intimate relationship with each patient's cancer journey. Equicare CS™ enables cancer centers to provide coordinated navigation, distress management, and survivorship care planning to improve clinical outcomes for patients and achieve regulatory compliance. Creating a chronic care model for cancer survivorship is the right thing to do for both patients and your organization. Equicare Health can help you do it. Follow us on Twitter @EquicareHealth.

New York, New York, United States

Relevant’s mission is to bring world-class software to people working on the front lines of America’s healthcare safety net. We build data and population health tools to help community health centers improve patient outcomes.

London, England, United Kingdom

At Medloop, we strongly believe in the potential for connected healthcare. As such, we are on a mission to close the loop between patients and doctors, enabling doctors to have a real-time overview of their patient population, and empowering patients to have better access to care. With prevention as its core focus, Medloop is on a mission to enrich the relationship between patients and doctors and transform healthcare from being reactive to becoming preventative. In order to realize its vision, Medloop leverages millions of patient-years data and best preventive practices from our partner, one of the largest Health- Maintenance-Organizations (HMO) in the world, to build an advanced rule-engine and predictive analytics system that is deployed via a physician dashboard and native patient mobile application. As such, Medloop promotes evidence-based preventative medicine to lower chronic disease incidence, promote better care management and disease outcomes, thus relieving the growing burden on the healthcare industry.

Miami, Florida, United States

At Spatially Health, we help value-based care organizations reduce costs, improve quality, and close care gaps by making social risk visible, measurable, and actionable at scale. We transform fragmented social care efforts into high-impact, data-driven operations. With real-time eligibility screening, referral automation, and national network access, your care team gets more done—without burning out. • 10x care team productivity • 30% faster social service connection • Real-time insight into patient-level risks Built for ACOs, MCOs, and Medicaid plans, we bring clarity to complexity so social risk becomes your most efficient lever for reducing avoidable utilization, improving care quality, and delivering better patient outcomes.

Palo Alto, California, United States

Provider of a population health management and health analytics platform. The company's cloud-based SaaS system provides data mining and analysis services to healthcare organizations, along with analysis tools tailored to individual practices and physician needs.