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Top 19 SaaS Companies in Saint Louis, United States, May 2026

As of May 2026, there are 19 SaaS companies based in Saint Louis. They have combined revenues of $1.1B and employ 870 employees. They've raised $63.1M in capital and serve 519 customers combined.

Companies
19
Revenue
$1.1B
Funding
$63.1M
Employees
870

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Top SaaS Companies in Saint Louis

Showing 10 of 6 companies ranked by annual revenue.

1
Netelligent Corporation

Saint Louis, Missouri, United States

Netelligent provides companies with the technologies they need to run their business (security, phone system, servers/virtualization)

Revenue
$88.9M
Customers
-
Year founded
2003
Funding
$25M
Team size
23
Growth
2318.18%
2
TCARE

Saint Louis, Missouri, United States

TCARE supports caregivers through the complexities of caregiving to help health plans, employers, and families get to a place of better care. It is a family caregiver support platform designed to prevent caregiver burnout and help keep care at home.

Revenue
$54.6M
Customers
-
Year founded
2014
Funding
-
Team size
97
Growth
-
3
Coolfire

Saint Louis, Missouri, United States

real-time situational awareness software

Revenue
$16.5M
Customers
-
Year founded
2010
Funding
$20.6M
Team size
19
Growth
-
4
Infoplus

Saint Louis, Missouri, United States

Infoplus is a powerful yet simple warehouse, inventory management, shipping software for e-Commerce and 3PL warehouses, retailers, distributors, and wholesalers.

Revenue
$15M
Customers
-
Year founded
2013
Funding
-
Team size
11
Growth
-
5
Native Pet

Saint Louis, MO, United States

Native Pet is a pet food and nutrition company that makes organic, highly effective, and limited-ingredient pet supplements for dogs and cats.

Revenue
$13.4M
Customers
-
Year founded
2017
Funding
-
Team size
55
Growth
-
6
US Cloud

Saint Louis, Missouri, United States

Provides reputable Microsoft enterprise support to clients world-wide. Enables Microsoft Premier (Unified) Support customers to enjoy ultra-responsive support from US citizens, saving 30-60% on support costs and freeing up funds to drive innovation

Revenue
$10M
Customers
-
Year founded
2006
Funding
-
Team size
124
Growth
-
Saint Louis, United States SaaS Companies | GetLatka