Top 843 SaaS Companies in Massachusetts, United States, May 2026

Boston, Massachusetts, United States

The AI-powered operations platform for your unique processes.

Boston, Massachusetts, United States

B2B SaaS platform for software purchasing management

Boston, Massachusetts, United States

Provider of a cyber-security and compliance platform designed to secure business-critical applications. The company's compliance platform includes preventative vulnerability and compliance controls, as well as real-time detection and incident response capabilities to reduce risks affecting critical business processes and data, enabling clients to seamlessly incorporate enterprise applications into existing risk and incident response management programs and automate the monitoring and protection of SAP and Oracle ERP, keeping them compliant and safe from insider and outsider threats.

Marlborough, Massachusetts, United States

insurance policy and billing administration solution

Boston, Massachusetts, United States

LastPass is a leading identity and password manager, making it easier to log in to life and work. Trusted by 100,000 businesses and millions of users, LastPass combines advanced security with effortless access for individuals, families, small business owners, and enterprise professionals. With LastPass, important credentials are protected and private – and always within reach. Learn more via www.lastpass.com.

Boston, Massachusetts, United States

ShopMy is a creator-centric ecosystem that links top brands with influential creators to facilitate partnerships. The platform offers tools for creating and managing influencer marketing campaigns.

Somerville, Massachusetts, United States

Sublime Systems develops technology to decarbonize cement-making, commercializing affordable, ultra-low-carbon cement through an electrochemical process.

Cambridge, Massachusetts, United States

Generate Biomedicines is a biotechnology company founded in 2018 and headquartered in Cambridge, Massachusetts. It specializes in using machine learning and biological engineering to create biomedicines.

Framingham, Massachusetts, United States

Definitive Healthcare is the leading provider of data and analytics, focusing on the business side of healthcare. The healthcare market is complex – our intelligence makes it clearer. We cut through the noise, offering the clarity you need to make smarter, faster, more strategic decisions. Because when you succeed, healthcare gets better for everyone. Making sense of the healthcare market starts with the right intelligence. Our powerful SaaS solutions combine proprietary data, analytics, and deep industry expertise to help biopharma, medtech, healthcare providers, and other leaders accelerate growth and make a bigger impact. We help you answer the critical questions you face every day—from identifying the right markets and audiences to accelerating commercialization and improving patient care. Our customers rely on our data and analytics for a variety of strategic use cases, including: • Total Addressable Market (TAM) definition • Audience segmentation • Decision-maker / ideal client identification • Patient acquisition and retention • Healthcare professional (HCP) targeting • Consumer targeting • Digital advertising / audience activation • Key opinion leader (KOL) identification & engagement • Clinical trends tracking & analysis • Commercial targeting • Market access strategy • Go-to-market strategy • Payor landscape intelligence Definitive Healthcare has expanded its global client base to 2,400+ and is headquartered in Framingham, Massachusetts, with offices across the U.S., Sweden, and India. We are recognized as a great place to work, including Built In’s 100 Best Places to Work in Boston. To learn more about how our healthcare data and analytics can help you accelerate growth and your impact on healthcare, visit us at www.definitivehc.com.

Newton, Massachusetts, United States

Examity, now part of Meazure Learning, was founded to provide flexible solutions through live, recorded, and automated online proctoring. The Examity proctoring platform will still be operational and used by test-takers until October 2024. At that point, all remotely proctored exams will have been migrated to the ProctorU Platform. If you’re a test-taker needing assistance with the Examity platform, please visit www.examity.com/test-taker-resource-center. If you are a prospective client looking for remote proctoring services, please visit www.meazurelearning.com to talk with one of our team members