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Top 45 SaaS Companies in Durham, United States, May 2026

As of May 2026, there are 45 SaaS companies based in Durham. They have combined revenues of $439.1M and employ 3.4K employees. They've raised $633.7M in capital and serve 38.9K customers combined.

Companies
45
Revenue
$439.1M
Funding
$633.7M
Employees
3.4K

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Top SaaS Companies in Durham

Showing 10 of 5 companies ranked by annual revenue.

1
PhotoniCare

Durham, North Carolina, United States

PhotoniCare is a medical device company that develops diagnostic tools to improve clinical outcomes and address unmet patient needs, particularly focusing on ear health with its OtoSight Middle Ear Scope.

Revenue
$9.8M
Customers
-
Year founded
2015
Funding
-
Team size
25
Growth
-
2
GTM Buddy

Durham, North Carolina, United States

Do you create content wikis and internal landing pages to help your reps find relevant content? Are you forcing your sellers to learn yet another tool to find content? Enabling your sales team goes beyond onboarding them or organizing sales content using folders and tags. Your reps need just-in-time enablement within their flow of work and in the context of a sales conversation. We built GTM Buddy to solve this very problem for modern revenue teams. GTM Buddy’s innovative revenue enablement solution combines never before seen just-in-time enablement with the best content analytics so that customer-facing reps deliver the best experience to their buyers. Help your sellers overcome their content discovery challenges and make them feel confident.

Revenue
$9.2M
Customers
-
Year founded
2020
Funding
-
Team size
61
Growth
-
3
Adwerx

Durham, North Carolina, United States

Adwerx is an industry-leading digital advertising automation platform that provides personalized, hyper-targeted, and fully-automated digital advertising solutions for real estate and mortgage companies. Scalable for businesses of any size, Adwerx executes advertising with the power needed for large enterprises and the simplicity expected for an individual agent. As a trusted partner to thousands of real estate and mortgage firms and their top producers, Adwerx enables its customers to stay ahead of the competition by reaching new audiences and nurturing existing relationships. For more information about Adwerx and its suite of digital advertising solutions, visit www.adwerx.com.

Revenue
$8.4M
Customers
-
Year founded
2013
Funding
-
Team size
76
Growth
-
4
restor3d

Durham, North Carolina, United States

restor3d specializes in personalized, 3D-printed orthopedic implants for shoulder, ankle, knee, and hip replacements, tailored to each patient's anatomy.

Revenue
$7.5M
Customers
-
Year founded
-
Funding
-
Team size
247
Growth
-
5
Arpio

Durham, North Carolina, United States

Recover from any outage in 10 minutes or less.

Revenue
$5M
Customers
-
Year founded
2018
Funding
-
Team size
22
Growth
-