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Top 16 SaaS Companies in South San Francisco, United States, May 2026

As of May 2026, there are 16 SaaS companies based in South San Francisco. They have combined revenues of $19.7B and employ 11.5K employees. They've raised $9.4B in capital and serve 1M customers combined.

Companies
16
Revenue
$19.7B
Funding
$9.4B
Employees
11.5K

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Top SaaS Companies in South San Francisco

Showing 10 of 3 companies ranked by annual revenue.

1
Firefly Bio

South San Francisco, California, United States

Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders, developing a novel platform to treat cancer.

Revenue
$7.4M
Customers
-
Year founded
2022
Funding
-
Team size
28
Growth
-
2
Brightest Minds

South San Francisco, California, United States

At BrightestMinds, we're incubating the Sales Development Reps of the future, supercharged with intent-driven data and tools under one solution. We've achieved 10x cost efficiency vs AdWords. We had cases when clients requested that we slow down, as they were unable to process so many leads. We work with tech startups and unicorns. Many of our clients doubled, tripled and quadrupled the number of SDRs assigned to help them with lead generation. Since 2017, we grew from one to a globally distributed team of over 50 high-performing, happy people that are dedicated to innovating and creating new ways to exceed in lead generation. Talk to us now; schedule a call via https://calendly.com/bmteam

Revenue
$6M
Customers
-
Year founded
2016
Funding
-
Team size
53
Growth
53.82%
3
Zenflow

South San Francisco, California, United States

Medical device that provides a more effective, less invasive…

Revenue
$5M
Customers
-
Year founded
2014
Funding
-
Team size
29
Growth
-
South San Francisco, United States SaaS Companies | GetLatka